B7-1/CD80产品信息
英文名称：Cluster of differentiation 80
中文名称：分化群80
靶点别称：Activation B7-1 antigen，LAB7，T-lymphocyte activation antigen CD80，CD80 Molecule，CD80 Antigen (CD28 Antigen Ligand 1， B7-1 Antigen)，B-Lymphocyte Activation Antigen B7，CTLA-4 Counter-Receptor B7.1，CD28LG1，BB1，Costimulatory Molecule Variant IgV-CD80，Costimulatory Factor CD80，CD80 Antigen，B7-1，B7.1，B7-1 Antigen，B7，CD80，CD28LG
表达区间及表达系统（Source）
Biotinylated Human B7-1, Fc,Avitag (B71-H82F2) is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # NP_005182.1).
Predicted N-terminus: Val 35
标记（Biotinylation）
Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
蛋白标记度（Biotin:Protein Ratio)
Passed as determined by the HABA assay / binding ELISA.
内毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
纯度（Purity）
>95% as determined by SDS-PAGE.
制剂（Formulation）
Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重构方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
质量管理控制体系（QMS）
质量管理体系（ISO, GMP）
质量优势
质控流程
分子背景
B7-1和B7-2及其受体CD28和CTLA-4构成了调节T细胞和B细胞反应的主要共刺激途径之一。尽管CTLA-4和CD28都可以与相同的配体结合，但CTLA-4与B7-1和B7-2的结合亲和力是CD28的20-100倍，并参与反应的下调。
B淋巴细胞活化抗原B7-1（简称B7）也称为分化簇80（CD80），是细胞表面球蛋白超家族的成员，在活化的B细胞、活化的T细胞、巨噬细胞和树突状细胞上表达。它是T细胞表面两种不同蛋白质的配体：CD28（用于自动调节和细胞间结合）和CTLA-4（用于减弱调节和细胞解离）。CD80与CD86协同工作以启动T细胞。CD80通过激活巨噬细胞中的NF-κB信号通路在诱导先天反应中发挥作用。因此，CD80被认为是自身性疾病和各种癌症的有希望的治疗靶点。
